Ontology highlight
ABSTRACT:
SUBMITTER: Awasthi S
PROVIDER: S-EPMC6158705 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Awasthi Sharad S Verma Mamta M Mahesh Arun A K Khan Mohd Imran MI Govindaraju Gayathri G Rajavelu Arumugam A Chavali Pavithra L PL Chavali Sreenivas S Dhayalan Arunkumar A
Nucleic acids research 20180701 12
Among the proteins predicted to be a part of the DExD box RNA helicase family, the functions of DDX49 are unknown. Here, we characterize the enzymatic activities and functions of DDX49 by comparing its properties with the well-studied RNA helicase, DDX39B. We find that DDX49 exhibits a robust ATPase and RNA helicase activity, significantly higher than that of DDX39B. DDX49 is required for the efficient export of poly (A)+ RNA from nucleus in a splicing-independent manner. Furthermore, DDX49 is a ...[more]