Ontology highlight
ABSTRACT:
SUBMITTER: Degtyareva NN
PROVIDER: S-EPMC6158780 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Degtyareva Natalya N NN Reddish Michael J MJ Sengupta Bidisha B Petty Jeffrey T JT
Biochemistry 20090301 11
The secondary structure of repeated trinucleotide sequences results in the development of several neurodegenerative diseases, and these studies consider the (CAG)(8) sequence that forms a stem-loop hairpin. The structural and thermodynamic properties of this hairpin are assessed using 2-aminopurine substitutions for adenine at six positions in this repeated sequence. Circular dichroism spectra and thermal denaturation experiments show that the secondary structure is not disturbed by the modifica ...[more]