Ontology highlight
ABSTRACT:
SUBMITTER: Aujla A
PROVIDER: S-EPMC6158887 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Aujla Amandeep A Linder Katherine K Iragavarapu Chaitanya C Karass Michael M Liu Delong D
Biomarker research 20180926
Recurrent gene mutations have been described with varying frequencies in myelodysplasia (MDS) /myeloproliferative neoplasm (MPN) overlap syndromes (MMOS). Recent work has placed significant focus on understanding the role of gene lesions involving the spliceosomal machinery in leukemogeneis. SRSF2 is a gene encoding critical spliceosomal proteins. SRSF2 mutations appear to play an important role in pathogenesis of MMOS, particularly in chronic myelomonocytic leukemia. Inhibition of splicing may ...[more]