Ontology highlight
ABSTRACT:
SUBMITTER: Dolfe L
PROVIDER: S-EPMC6159705 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Dolfe Lisa L Tambaro Simone S Tigro Helene H Del Campo Marta M Hoozemans Jeroen J M JJM Wiehager Birgitta B Graff Caroline C Winblad Bengt B Ankarcrona Maria M Kaldmäe Margit M Teunissen Charlotte E CE Rönnbäck Annica A Johansson Jan J Presto Jenny J
Journal of Alzheimer's disease reports 20180216 1
Alzheimer's disease (AD) is the most common form of dementia and there is no successful treatment available. Evidence suggests that fibril formation of the amyloid β-peptide (Aβ) is a major underlying cause of AD, and treatment strategies that reduce the toxic effects of Aβ amyloid are sought for. The BRICHOS domain is found in several proteins, including Bri2 (also called integral membrane protein 2B (ITM2B)), mutants of which are associated with amyloid and neurodegeneration, and Bri3 (ITM2C). ...[more]