Ontology highlight
ABSTRACT:
SUBMITTER: Biverstal H
PROVIDER: S-EPMC7730125 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Biverstål Henrik H Kumar Rakesh R Schellhaus Anna Katharina AK Sarr Médoune M Dantuma Nico P NP Abelein Axel A Johansson Jan J
Scientific reports 20201210 1
Amyloid fibrils are mechanically robust and partly resistant to proteolytic degradation, making them potential candidates for scaffold materials in cell culture, tissue engineering, drug delivery and other applications. Such applications of amyloids would benefit from the possibility to functionalize the fibrils, for example by adding growth factors or cell attachment sites. The BRICHOS domain is found in a family of human proteins that harbor particularly amyloid-prone regions and can reduce ag ...[more]