DNA repair defects and implications for immunotherapy.
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ABSTRACT:
SUBMITTER: Bever KM
PROVIDER: S-EPMC6159999 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
DNA repair defects and implications for immunotherapy.
Bever Katherine M KM Le Dung T DT
The Journal of clinical investigation 20181001 10
A complex DNA repair machinery has evolved to protect genomic integrity in the face of a myriad of DNA damage sources. When DNA repair fails, this damage can lead to carcinogenesis and tumor genomic instability. Indeed, many heritable cancer predisposition syndromes are attributable to germline defects in DNA repair pathways. On the other hand, these defects may also portend particular vulnerabilities of the cancer and may be exploited therapeutically. Most recently this has been demonstrated in ...[more]
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