Ontology highlight
ABSTRACT:
SUBMITTER: Furukawa Y
PROVIDER: S-EPMC6160046 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Furukawa Yoshiaki Y Lim Carolyn C Tosha Takehiko T Yoshida Koki K Hagai Tomoaki T Akiyama Shuji S Watanabe Shoji S Nakagome Kenta K Shiro Yoshitsugu Y
PloS one 20180927 9
Heavy metal-associated (HMA) domains bind metal ions at its Cys-x-x-Cys (CxxC) motif and constitute an intracellular network for trafficking of metal ions for utilization and detoxification. We thus expect that novel metalloproteins can be identified by screening proteins interacting with a HMA domain. In this study, we performed yeast two-hybrid screening of the human proteome and found an uncharacterized protein encoded as open reading frame 123 in chromosome 1 (C1orf123) that can interact spe ...[more]