Ontology highlight
ABSTRACT:
SUBMITTER: Smith AT
PROVIDER: S-EPMC4543396 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Smith Aaron T AT Barupala Dulmini D Stemmler Timothy L TL Rosenzweig Amy C AC
Nature chemical biology 20150720 9
The P1B-ATPases, which couple cation transport across membranes to ATP hydrolysis, are central to metal homeostasis in all organisms. An important feature of P1B-ATPases is the presence of soluble metal binding domains (MBDs) that regulate transport activity. Only one type of MBD has been characterized extensively, but bioinformatics analyses indicate that a diversity of MBDs may exist in nature. Here we report the biochemical, structural and functional characterization of a new MBD from the Cup ...[more]