Ontology highlight
ABSTRACT:
SUBMITTER: Menegas W
PROVIDER: S-EPMC6160326 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Menegas William W Akiti Korleki K Amo Ryunosuke R Uchida Naoshige N Watabe-Uchida Mitsuko M
Nature neuroscience 20180903 10
Midbrain dopamine neurons are well known for their role in reward-based reinforcement learning. We found that the activity of dopamine axons in the posterior tail of the striatum (TS) scaled with the novelty and intensity of external stimuli, but did not encode reward value. We demonstrated that the ablation of TS-projecting dopamine neurons specifically inhibited avoidance of novel or high-intensity stimuli without affecting animals' initial avoidance responses, suggesting a role in reinforceme ...[more]