Ontology highlight
ABSTRACT:
SUBMITTER: Mudd JC
PROVIDER: S-EPMC6160474 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Mudd Joseph C JC Busman-Sahay Kathleen K DiNapoli Sarah R SR Lai Stephen S Sheik Virginia V Lisco Andrea A Deleage Claire C Richardson Brian B Palesch David J DJ Paiardini Mirko M Cameron Mark M Sereti Irini I Reeves R Keith RK Estes Jacob D JD Brenchley Jason M JM
Nature communications 20180927 1
Innate lymphoid cells (ILCs) play critical roles in mucosal barrier defense and tissue homeostasis. While ILCs are depleted in HIV-1 infection, this phenomenon is not a generalized feature of all viral infections. Here we show in untreated SIV-infected rhesus macaques (RMs) that ILC3s are lost rapidly in mesenteric lymph nodes (MLNs), yet preserved in SIV<sup>+</sup> RMs with pharmacologic or natural control of viremia. In healthy uninfected RMs, experimental depletion of CD4<sup>+</sup> T cells ...[more]