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Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells

ABSTRACT: Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells

PROVIDER: PRJNA476787 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7367600_1.fastq.gz	Fastqsanger.gz
	SRR7367600_2.fastq.gz	Fastqsanger.gz
	SRR7367591_1.fastq.gz	Fastqsanger.gz
	SRR7367591_2.fastq.gz	Fastqsanger.gz
	SRR7367601_1.fastq.gz	Fastqsanger.gz

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Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells.

Project description:Innate lymphoid cells (ILCs) play critical roles in mucosal barrier defense and tissue homeostasis. While ILCs are depleted in HIV-1 infection, this phenomenon is not a generalized feature of all viral infections. Here we show in untreated SIV-infected rhesus macaques (RMs) that ILC3s are lost rapidly in mesenteric lymph nodes (MLNs), yet preserved in SIV+ RMs with pharmacologic or natural control of viremia. In healthy uninfected RMs, experimental depletion of CD4+ T cells in combination with dextran sodium sulfate (DSS) is sufficient to reduce ILC frequencies in the MLN. In this setting and in chronic SIV+ RMs, IL-7R? chain expression diminishes on ILC3s in contrast to the IL-18R? chain expression which remains stable. In HIV-uninfected patients with durable CD4+ T cell deficiency (deemed idiopathic CD4+ lymphopenia), similar ILC deficiencies in blood were observed, collectively identifying determinants of ILC homeostasis in primates and potential mechanisms underlying their depletion in HIV/SIV infection.

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Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells

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