Ontology highlight
ABSTRACT:
SUBMITTER: Diener C
PROVIDER: S-EPMC6160487 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Diener Caroline C Hart Martin M Alansary Dalia D Poth Vanessa V Walch-Rückheim Barbara B Menegatti Jennifer J Grässer Friedrich F Fehlmann Tobias T Rheinheimer Stefanie S Niemeyer Barbara A BA Lenhof Hans-Peter HP Keller Andreas A Meese Eckart E
Cell death & disease 20180927 10
Adjusting intracellular calcium signaling is an important feature in the regulation of immune cell function and survival. Here we show that miR-34a-5p, a small non-coding RNA that is deregulated in many common diseases, is a regulator of store-operated Ca<sup>2+</sup> entry (SOCE) and calcineurin signaling. Upon miR-34a-5p overexpression, we observed both a decreased depletion of ER calcium content and a decreased Ca<sup>2+</sup> influx through Ca<sup>2+</sup> release-activated Ca<sup>2+</sup> c ...[more]