Ontology highlight
ABSTRACT:
SUBMITTER: Tong Y
PROVIDER: S-EPMC6160570 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Tong Yi Y Jiao Qian Q Liu Yuanru Y Lv Jiankun J Wang Rui R Zhu Lili L
Frontiers in pharmacology 20180921
Pulmonary arterial hypertension (PAH) is a progressive disease caused by increased pulmonary artery pressure and pulmonary vascular resistance, eventually leading to right heart failure until death. Soluble guanylate cyclase (sGC) has been regarded as an attractive drug target in treating PAH. In this study, we discovered that maprotiline, a tetracyclic antidepressant, bound to the full-length recombinant sGC with a high affinity (<i>K</i> <sub>D</sub> = 0.307 μM). Further study demonstrated tha ...[more]