Ontology highlight
ABSTRACT:
SUBMITTER: Apartsin EK
PROVIDER: S-EPMC6161142 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Apartsin Evgeny K EK Grigoryeva Alina E AE Malrin-Fournol Audrey A Ryabchikova Elena I EI Venyaminova Alya G AG Mignani Serge S Caminade Anne-Marie AM Majoral Jean-Pierre JP
Pharmaceutics 20180806 3
In this work, we report the assemblage of hydrogels from phosphorus dendrimers in the presence of biocompatible additives and the study of their interactions with nucleic acids. As precursors for hydrogels, phosphorus dendrimers of generations 1⁻3 based on the cyclotriphosphazene core and bearing ammonium or pyridinium acetohydrazones (Girard reagents) on the periphery have been synthesized. The gelation was done by the incubation of dendrimer solutions in water or phosphate-buffered saline in t ...[more]