Next Generation Cancer Vaccines-Make It Personal!
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ABSTRACT:
SUBMITTER: Terbuch A
PROVIDER: S-EPMC6161279 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Next Generation Cancer Vaccines-Make It Personal!
Terbuch Angelika A Lopez Juanita J
Vaccines 20180809 3
Dramatic success in cancer immunotherapy has been achieved over the last decade with the introduction of checkpoint inhibitors, leading to response rates higher than with chemotherapy in certain cancer types. These responses are often restricted to cancers that have a high mutational burden and show pre-existing T-cell infiltrates. Despite extensive efforts, therapeutic vaccines have been mostly unsuccessful in the clinic. With the introduction of next generation sequencing, the identification o ...[more]
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