MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study.

ABSTRACT:

Background

With the shift of research focus towards the pre-dementia stage of Alzheimer's disease (AD), there is an urgent need for reliable, non-invasive biomarkers to predict amyloid pathology. The aim of this study was to assess whether easily obtainable measures from structural MRI, combined with demographic data, cognitive data and apolipoprotein E (APOE) ε4 genotype, can be used to predict amyloid pathology using machine-learning classification.

Methods

We examined 810 subjects with structural MRI data and amyloid markers from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, including subjects with normal cognition (CN, n = 337, age 66.5 ± 7.2, 50% female, 27% amyloid positive), mild cognitive impairment (MCI, n =

SUBMITTER: Ten Kate M 

PROVIDER: S-EPMC6161396 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature