Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors.
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ABSTRACT:
SUBMITTER: Guzel-Akdemir O
PROVIDER: S-EPMC6161604 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
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Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors.
Güzel-Akdemir Özlen Ö Angeli Andrea A Demir Kübra K Supuran Claudiu T CT Akdemir Atilla A
Journal of enzyme inhibition and medicinal chemistry 20181201 1
A small collection of 26 structurally novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group, were synthesised and tested in enzyme inhibition assays against the tumour-associated hCA IX enzyme. Inhibition constants in the lower micromolar region (K<sub>I</sub> < 25 μM) have been measured for 17 of the 26 compounds. Even though the K<sub>I</sub> values are relatively weak, the fact that they do not contain a sulphonamide moiety suggests that these compo ...[more]
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