Ontology highlight
ABSTRACT:
SUBMITTER: McCulloch R
PROVIDER: S-EPMC6162063 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
McCulloch Richard R Cobbold Christina A CA Figueiredo Luisa L Jackson Andrew A Morrison Liam J LJ Mugnier Monica R MR Papavasiliou Nina N Schnaufer Achim A Matthews Keith K
Emerging topics in life sciences 20171201 6
Many pathogens evade host immunity by periodically changing the proteins they express on their surface - a phenomenon termed antigenic variation. An extreme form of antigenic variation, based around switching the composition of a Variant Surface Glycoprotein (VSG) coat, is exhibited by the African trypanosome <i>Trypanosoma brucei</i>, which causes human disease. The molecular details of VSG switching in <i>T. brucei</i> have been extensively studied over the last three decades, revealing in inc ...[more]