Ontology highlight
ABSTRACT:
SUBMITTER: Zhou W
PROVIDER: S-EPMC6162094 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Zhou Weisong W Zhang Jian J Toki Shinji S Goleniewska Kasia K Johnson Marc O MO Bloodworth Melissa H MH Newcomb Dawn C DC Peebles R Stokes RS
Journal of immunology (Baltimore, Md. : 1950) 20180820 7
IL-33 has pleiotropic functions in immune responses and promotes the development of allergic diseases and asthma. IL-33 induces Th2 differentiation and enhances type 2 cytokine production by CD4<sup>+</sup> T cells. However, the regulation of IL-33-driven type 2 cytokine responses is not fully defined. In this study, we investigated the effect of PGI<sub>2</sub>, a lipid mediator formed in the cyclooxygenase pathway of arachidonic acid metabolism, on naive CD4<sup>+</sup> T cell activation, prol ...[more]