Ontology highlight
ABSTRACT:
SUBMITTER: Harrison CA
PROVIDER: S-EPMC6162102 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Harrison Christy A CA Laubitz Daniel D Ohland Christina L CL Midura-Kiela Monica T MT Patil Karuna K Besselsen David G DG Jamwal Deepa R DR Jobin Christian C Ghishan Fayez K FK Kiela Pawel R PR
Mucosal immunology 20180606 5
Intestinal epithelial Na<sup>+</sup>/H<sup>+</sup> exchange facilitated by the apical NHE3 (Slc9a3) is a highly regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3<sup>-/-</sup> mice develop spontaneous, bacterially mediated colitis, and IBD-like dysbiosis. Disruption of epithelial Na<sup>+</sup>/H<sup>+</sup> exchange in IBD may thus represent a host response contributing to the altered gut microbial ecology, and may play a pivotal role in modulating the ...[more]