Ontology highlight
ABSTRACT:
SUBMITTER: Jacob N
PROVIDER: S-EPMC6162160 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Jacob Noam N Jacobs Jonathan P JP Kumagai Kotaro K Ha Connie W Y CWY Kanazawa Yoshitake Y Lagishetty Venu V Altmayer Katherine K Hamill Ariel M AM Von Arx Aimee A Sartor R Balfour RB Devkota Suzanne S Braun Jonathan J Michelsen Kathrin S KS Targan Stephan R SR Shih David Q DQ
Mucosal immunology 20180709 5
Tumor necrosis factor-like cytokine 1A (TL1A, TNFSF15) is implicated in inflammatory bowel disease (IBD), modulating the location and severity of intestinal inflammation and fibrosis. TL1A expression is increased in inflamed gut mucosa and associated with fibrostenosing Crohn's disease. Tl1a-overexpression in mice lead to spontaneous ileitis, and exacerbated induced proximal colitis and fibrosis. IBD is associated with shifts in the gut microbiome, but the effect of differing microbial populatio ...[more]