Ontology highlight
ABSTRACT:
SUBMITTER: Shaw KA
PROVIDER: S-EPMC6162182 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Shaw Kelly A KA Cutler David J DJ Okou David D Dodd Anne A Aronow Bruce J BJ Haberman Yael Y Stevens Christine C Walters Thomas D TD Griffiths Anne A Baldassano Robert N RN Noe Joshua D JD Hyams Jeffrey S JS Crandall Wallace V WV Kirschner Barbara S BS Heyman Melvin B MB Snapper Scott S Guthery Stephen S Dubinsky Marla C MC Shapiro Jason M JM Otley Anthony R AR Daly Mark M Denson Lee A LA Kugathasan Subra S Zwick Michael E ME
Genes and immunity 20180328 2
In the United States, approximately 5% of individuals with inflammatory bowel disease (IBD) are younger than 20 years old. Studies of pediatric cohorts can provide unique insights into genetic architecture of IBD, which includes Crohn's disease (CD) and ulcerative colitis (UC). Large genome-wide association studies have found more than 200 IBD-associated loci but explain a minority of disease variance for CD and UC. We sought to characterize the contribution of rare variants to disease developme ...[more]