Ontology highlight
ABSTRACT:
SUBMITTER: Loudon BL
PROVIDER: S-EPMC6162228 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Loudon Brodie L BL Ntatsaki Eleana E Newsome Simon S Halliday Brian B Lota Amrit A Ali Aamir A Malley Tamir T Selvendran Subothini S Aggarwal Nikhil N Lam Willis W Donovan Jackie J Auger Dominque D Raphael Claire E CE Flynn Paul D PD Pennell Dudley J DJ Vassiliou Vassilios S VS Prasad Sanjay K SK
Scientific reports 20180928 1
Left ventricular myocardial fibrosis in patients with aortic stenosis (AS) confers worse prognosis. Plasma osteoprotegerin (OPG), a cytokine from the TNF receptor family, correlates with the degree of valve calcification in AS, reflecting the activity of the tissue RANKL/RANK/OPG (receptor activator of nuclear factor κΒ ligand/RANK/osteoprotegerin) axis, and is associated with poorer outcomes in AS. Its association with myocardial fibrosis is unknown. We hypothesised that OPG levels would reflec ...[more]