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Multilocus genetic risk score for diabetic retinopathy in the Han Chinese population of Taiwan.


ABSTRACT: The aim of this study is to explore the effect of genetic variation on diabetic retinopathy (DR) risk in a Taiwanese population. The logistic regression model was used to evaluate the relationship between DR status and risk factors, including the conventional parameters and genetic risk score (GRS). Candidate single nucleotide polymorphisms (SNPs) in GRS were selected based on previous reports with a combined P?

SUBMITTER: Liao WL 

PROVIDER: S-EPMC6162301 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Multilocus genetic risk score for diabetic retinopathy in the Han Chinese population of Taiwan.

Liao Wen-Ling WL   Lin Jang-Ming JM   Chen Wen-Lu WL   Hsieh Ming-Chia MC   Wu Chia-Ming CM   Chang Ya-Wen YW   Huang Yu-Chuen YC   Tsai Fuu-Jen FJ  

Scientific reports 20180928 1


The aim of this study is to explore the effect of genetic variation on diabetic retinopathy (DR) risk in a Taiwanese population. The logistic regression model was used to evaluate the relationship between DR status and risk factors, including the conventional parameters and genetic risk score (GRS). Candidate single nucleotide polymorphisms (SNPs) in GRS were selected based on previous reports with a combined P < 10<sup>-4</sup> (genome-wide association) and P < 0.05 (meta-analysis). In total, 5  ...[more]

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