Two-pore channels and disease.
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ABSTRACT:
SUBMITTER: Patel S
PROVIDER: S-EPMC6162333 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Two-pore channels and disease.
Patel Sandip S Kilpatrick Bethan S BS
Biochimica et biophysica acta. Molecular cell research 20180507 11 Pt B
Two-pore channels (TPCs) are Ca<sup>2+</sup>-permeable endo-lysosomal ion channels subject to multi-modal regulation. They mediate their physiological effects through releasing Ca<sup>2+</sup> from acidic organelles in response to cues such as the second messenger, NAADP. Here, we review emerging evidence linking TPCs to disease. We discuss how perturbing both local and global Ca<sup>2+</sup> changes mediated by TPCs through chemical and/or molecular manipulations can induce or reverse disease p ...[more]
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