Ontology highlight
ABSTRACT:
SUBMITTER: Chew YL
PROVIDER: S-EPMC6162336 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Chew Yee Lian YL Tanizawa Yoshinori Y Cho Yongmin Y Zhao Buyun B Yu Alex J AJ Ardiel Evan L EL Rabinowitch Ithai I Bai Jihong J Rankin Catharine H CH Lu Hang H Beets Isabel I Schafer William R WR
Neuron 20180823 6
Sensitization is a simple form of behavioral plasticity by which an initial stimulus, often signaling danger, leads to increased responsiveness to subsequent stimuli. Cross-modal sensitization is an important feature of arousal in many organisms, yet its molecular and neural mechanisms are incompletely understood. Here we show that in C. elegans, aversive mechanical stimuli lead to both enhanced locomotor activity and sensitization of aversive chemosensory pathways. Both locomotor arousal and cr ...[more]