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Association between Cigarette Smoking Status and Composition of Gut Microbiota: Population-Based Cross-Sectional Study.


ABSTRACT: There have been few large-scale studies on the relationship between smoking and gut microbiota. We investigated the relationship between smoking status and the composition of gut microbiota. This was a population-based cross-sectional study using Healthcare Screening Center cohort data. A total of 758 men were selected and divided into three groups: never (n = 288), former (n = 267), and current smokers (n = 203). Among the three groups, there was no difference in alpha diversity, however, Jaccard-based beta diversity showed significant difference (p = 0.015). Pairwise permutational multivariate analysis of variance (PERMANOVA) tests between never and former smokers did not show a difference; however, there was significant difference between never and current smokers (p = 0.017) and between former and current smokers (p = 0.011). Weighted UniFrac-based beta diversity also showed significant difference among the three groups (p = 0.038), and pairwise PERMANOVA analysis of never and current smokers showed significant difference (p = 0.01). In the analysis of bacterial composition, current smokers had an increased proportion of the phylum Bacteroidetes with decreased Firmicutes and Proteobacteria compared with never smokers, whereas there were no differences between former and never smokers. In conclusion, gut microbiota composition of current smokers was significantly different from that of never smokers. Additionally, there was no difference in gut microbiota composition between never and former smokers.

SUBMITTER: Lee SH 

PROVIDER: S-EPMC6162563 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Association between Cigarette Smoking Status and Composition of Gut Microbiota: Population-Based Cross-Sectional Study.

Lee Su Hwan SH   Yun Yeojun Y   Kim Soo Jung SJ   Lee Eun-Ju EJ   Chang Yoosoo Y   Ryu Seungho S   Shin Hocheol H   Kim Hyung-Lae HL   Kim Han-Na HN   Lee Jin Hwa JH  

Journal of clinical medicine 20180914 9


There have been few large-scale studies on the relationship between smoking and gut microbiota. We investigated the relationship between smoking status and the composition of gut microbiota. This was a population-based cross-sectional study using Healthcare Screening Center cohort data. A total of 758 men were selected and divided into three groups: never (<i>n</i> = 288), former (<i>n</i> = 267), and current smokers (<i>n</i> = 203). Among the three groups, there was no difference in alpha dive  ...[more]

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