Ontology highlight
ABSTRACT:
SUBMITTER: Crispin M
PROVIDER: S-EPMC6163090 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Annual review of biophysics 20180329
Vaccine design efforts against the human immunodeficiency virus (HIV) have been greatly stimulated by the observation that many infected patients eventually develop highly potent broadly neutralizing antibodies (bnAbs). Importantly, these bnAbs have evolved to recognize not only the two protein components of the viral envelope protein (Env) but also the numerous glycans that form a protective barrier on the Env protein. Because Env is heavily glycosylated compared to host glycoproteins, the glyc ...[more]