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Enhanced Effect of Combining Chlorogenic Acid on Selenium Nanoparticles in Inhibiting Amyloid ? Aggregation and Reactive Oxygen Species Formation In Vitro.

ABSTRACT: The deposition of amyloid-? (A?) plaques and formation of neurotoxic reactive oxygen species (ROS) is a significant pathological signature of Alzheimer's disease (AD). Herein, a novel strategy is reported for combining the unique A? absorption property of selenium nanoparticles with the natural antioxidant agent chlorogenic acid (CGA) to form CGA@SeNPs. The in vitro biological evaluation revealed that CGA could clear the ROS induced by A?40 aggregates, but it did not inhibit the A?40 aggregation and cell membrane damage which were also caused by A?40 aggregates. Interestingly, CGA@SeNPs show an enhanced inhibition effect on A?40 aggregation and, more importantly, protect PC12 cells from A? aggregation-induced cell death. It is believed that CGA@SeNPs are more efficient than CGA in reducing A?40 toxic in long-term use.

SUBMITTER: Yang L

PROVIDER: S-EPMC6163123 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Enhanced Effect of Combining Chlorogenic Acid on Selenium Nanoparticles in Inhibiting Amyloid β Aggregation and Reactive Oxygen Species Formation In Vitro.

Yang Licong L Wang Na N Zheng Guodong G

Nanoscale research letters 20180929 1

The deposition of amyloid-β (Aβ) plaques and formation of neurotoxic reactive oxygen species (ROS) is a significant pathological signature of Alzheimer's disease (AD). Herein, a novel strategy is reported for combining the unique Aβ absorption property of selenium nanoparticles with the natural antioxidant agent chlorogenic acid (CGA) to form CGA@SeNPs. The in vitro biological evaluation revealed that CGA could clear the ROS induced by Aβ40 aggregates, but it did not inhibit the Aβ40 aggregation ...[more]

PMID: 30269259

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