Ontology highlight
ABSTRACT:
SUBMITTER: Rajoli RKR
PROVIDER: S-EPMC6166436 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Rajoli R K R RKR Podany A T AT Moss D M DM Swindells S S Flexner C C Owen A A Siccardi M M
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20180801 8
<h4>Setting</h4>Anti-tuberculosis formulations necessitate uninterrupted treatment to cure tuberculosis (TB), but are characterised by suboptimal adherence, which jeopardises therapeutic efficacy. Long-acting injectable (LAI) formulations or implants could address these associated issues.<h4>Objective</h4>niazid, rifapentine, bedaquiline and delamanid-in adults for treatment for latent tuberculous infection (LTBI).<h4>Design</h4>PBPK models were developed and qualified against available clinical ...[more]