Ontology highlight
ABSTRACT:
SUBMITTER: Tian X
PROVIDER: S-EPMC6166886 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Tian Xi X Werner Michael E ME Roche Kyle C KC Hanson Ariel D AD Foote Henry P HP Yu Stephanie K SK Warner Samuel B SB Copp Jonathan A JA Lara Haydee H Wauthier Eliane L EL Caster Joseph M JM Herring Laura E LE Zhang Longzhen L Tepper Joel E JE Hsu David S DS Zhang Tian T Reid Lola M LM Wang Andrew Z AZ
Nature biomedical engineering 20180423 6
Metastatic disease remains the primary cause of mortality in cancer patients. Yet the number of available in vitro models to study metastasis is limited by challenges in the recapitulation of the metastatic microenvironment in vitro, and by difficulties in maintaining colonized-tissue specificity in the expansion and maintenance of metastatic cells. Here, we show that decellularized scaffolds that retain tissue-specific extracellular-matrix components and bound signalling molecules enable, when ...[more]