Ontology highlight
ABSTRACT:
SUBMITTER: Uppala JK
PROVIDER: S-EPMC6167009 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Uppala Jagadeesh Kumar JK Ghosh Chandrima C Sathe Leena L Dey Madhusudan M
FEBS letters 20180919 18
Protein kinases phosphorylate specific amino acid residues of substrate proteins and regulate many cellular processes. Specificity for phosphorylation depends on the accessibility of these residues, and more importantly, kinases have preferences for certain residues flanking the phospho-acceptor site. Translation initiation factor 2α [eukaryotic translation initiation factor 2α (eIF2α)] kinase phosphorylates serine51 (Ser51) of eIF2α and downregulates cellular protein synthesis. Structural infor ...[more]