Ontology highlight
ABSTRACT:
SUBMITTER: Albers E
PROVIDER: S-EPMC6167640 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Albers Eliene E Sbroggiò Mauro M Pladevall-Morera David D Bizard Anna H AH Avram Alexandra A Gonzalez Patricia P Martin-Gonzalez Javier J Hickson Ian D ID Lopez-Contreras Andres J AJ
Cell reports 20180901 12
PICH is a DNA translocase necessary for the resolution of ultrafine anaphase DNA bridges and to ensure the fidelity of chromosomal segregation. Here, we report the generation of an animal model deficient for PICH that allowed us to investigate its physiological relevance. Pich KO mice lose viability during embryonic development due to a global accumulation of DNA damage. However, despite the presence of chromosomal instability, extensive p53 activation, and increased apoptosis throughout the emb ...[more]