Ontology highlight
ABSTRACT:
SUBMITTER: Saghy E
PROVIDER: S-EPMC6168298 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Sághy Éva É Payrits Maja M Bíró-Sütő Tünde T Skoda-Földes Rita R Szánti-Pintér Eszter E Erostyák János J Makkai Géza G Sétáló György G Kollár László L Kőszegi Tamás T Csepregi Rita R Szolcsányi János J Helyes Zsuzsanna Z Szőke Éva É
Journal of lipid research 20180809 10
Transient Receptor Potential (TRP) cation channels, like the TRP Vanilloid 1 (TRPV1) and TRP Ankyrin 1 (TRPA1), are expressed on primary sensory neurons. These thermosensor channels play a role in pain processing. We have provided evidence previously that lipid raft disruption influenced the TRP channel activation, and a carboxamido-steroid compound (C1) inhibited TRPV1 activation. Therefore, our aim was to investigate whether this compound exerts its effect through lipid raft disruption and the ...[more]