Recent Insight into Lipid Binding and Lipid Modulation of Pentameric Ligand-Gated Ion Channels.
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ABSTRACT:
SUBMITTER: Ananchenko A
PROVIDER: S-EPMC9221113 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
Recent Insight into Lipid Binding and Lipid Modulation of Pentameric Ligand-Gated Ion Channels.
Ananchenko Anna A Hussein Toka O K TOK Mody Deepansh D Thompson Mackenzie J MJ Baenziger John E JE
Biomolecules 20220610 6
Pentameric ligand-gated ion channels (pLGICs) play a leading role in synaptic communication, are implicated in a variety of neurological processes, and are important targets for the treatment of neurological and neuromuscular disorders. Endogenous lipids and lipophilic compounds are potent modulators of pLGIC function and may help shape synaptic communication. Increasing structural and biophysical data reveal sites for lipid binding to pLGICs. Here, we update our evolving understanding of pLGIC- ...[more]
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