Dataset Information

Genomic history of the Sardinian population.

ABSTRACT: The population of the Mediterranean island of Sardinia has made important contributions to genome-wide association studies of complex disease traits and, based on ancient DNA studies of mainland Europe, Sardinia is hypothesized to be a unique refuge for early Neolithic ancestry. To provide new insights on the genetic history of this flagship population, we analyzed 3,514 whole-genome sequenced individuals from Sardinia. Sardinian samples show elevated levels of shared ancestry with Basque individuals, especially samples from the more historically isolated regions of Sardinia. Our analysis also uniquely illuminates how levels of genetic similarity with mainland ancient DNA samples varies subtly across the island. Together, our results indicate that within-island substructure and sex-biased processes have substantially impacted the genetic history of Sardinia. These results give new insight into the demography of ancestral Sardinians and help further the understanding of sharing of disease risk alleles between Sardinia and mainland populations.

SUBMITTER: Chiang CWK

PROVIDER: S-EPMC6168346 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Genomic history of the Sardinian population.

Chiang Charleston W K CWK Marcus Joseph H JH Sidore Carlo C Biddanda Arjun A Al-Asadi Hussein H Zoledziewska Magdalena M Pitzalis Maristella M Busonero Fabio F Maschio Andrea A Pistis Giorgio G Steri Maristella M Angius Andrea A Lohmueller Kirk E KE Abecasis Goncalo R GR Schlessinger David D Cucca Francesco F Novembre John J

Nature genetics 20180917 10

The population of the Mediterranean island of Sardinia has made important contributions to genome-wide association studies of complex disease traits and, based on ancient DNA studies of mainland Europe, Sardinia is hypothesized to be a unique refuge for early Neolithic ancestry. To provide new insights on the genetic history of this flagship population, we analyzed 3,514 whole-genome sequenced individuals from Sardinia. Sardinian samples show elevated levels of shared ancestry with Basque indivi ...[more]

PMID: 30224645

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Dataset Information

Genomic history of the Sardinian population.

Publications

Genomic history of the Sardinian population.

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