Ontology highlight
ABSTRACT:
SUBMITTER: Parisi T
PROVIDER: S-EPMC6168347 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Parisi Tiziana T Balsamo Michele M Gertler Frank F Lees Jacqueline A JA
Molecular carcinogenesis 20180826 11
Altered cell polarity and migration are hallmarks of cancer and metastases. Here we show that inactivation of the retinoblastoma gene (Rb) tumor suppressor causes defects in tissue closure that reflect the inability of Rb null epithelial cells to efficiently migrate and polarize. These defects occur independently of pRB's anti-proliferative role and instead correlate with upregulation of RhoA signaling and mislocalization of apical-basal polarity proteins. Notably, concomitant inactivation of tp ...[more]