Ontology highlight
ABSTRACT:
SUBMITTER: Gao N
PROVIDER: S-EPMC2885664 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Genes & development 20100601 12
In contrast to our significant understanding of signaling cascades that determine cell polarity in lower eukaryotic or immortalized cells, little is known about the transcriptional program that governs mammalian epithelial polarization in vivo. Here we show, using conditional gene ablation and three-dimensional tissue culture, that the homeobox transcription factor Cdx2 controls apical-basolateral polarity in mouse enterocytes and human colonic epithelial cells. Cdx2 regulates a comprehensive ge ...[more]