Association of tumor-infiltrating T-cell density with molecular subtype, racial ancestry and clinical outcomes in prostate cancer.
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ABSTRACT:
SUBMITTER: Kaur HB
PROVIDER: S-EPMC6168349 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Association of tumor-infiltrating T-cell density with molecular subtype, racial ancestry and clinical outcomes in prostate cancer.
Kaur Harsimar B HB Guedes Liana B LB Lu Jiayun J Maldonado Laneisha L Reitz Logan L Barber John R JR De Marzo Angelo M AM Tosoian Jeffrey J JJ Tomlins Scott A SA Schaeffer Edward M EM Joshu Corinne E CE Sfanos Karen S KS Lotan Tamara L TL
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20180530 10
The inflammatory microenvironment plays an important role in the pathogenesis and progression of tumors and may be associated with somatic genomic alterations. We examined the association of tumor-infiltrating T-cell density with clinical-pathologic variables, tumor molecular subtype, and oncologic outcomes in surgically treated primary prostate cancer occurring in patients of European-American or African-American ancestry. We evaluated 312 primary prostate tumors, enriched for patients with Afr ...[more]
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