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Short-term interval training alters brain glucose metabolism in subjects with insulin resistance.

ABSTRACT: Brain insulin-stimulated glucose uptake (GU) is increased in obese and insulin resistant subjects but normalizes after weight loss along with improved whole-body insulin sensitivity. Our aim was to study whether short-term exercise training (moderate intensity continuous training (MICT) or sprint interval training (SIT)) alters substrates for brain energy metabolism in insulin resistance. Sedentary subjects ( n?=?21, BMI 23.7-34.3?kg/m2, age 43-55?y) with insulin resistance were randomized into MICT ( n?=?11, intensity?60% of VO2peak) or SIT ( n?=?10, all-out) groups for a two-week training intervention. Brain GU during insulin stimulation and fasting brain free fatty acid uptake (FAU) was measured using PET. At baseline, brain GU was positively associated with the fasting insulin level and negatively with the whole-body insulin sensitivity. The whole-body insulin sensitivity improved with both training modes (20%, p?=?0.007), while only SIT led to an increase in aerobic capacity (5%, p?=?0.03). SIT also reduced insulin-stimulated brain GU both in global cortical grey matter uptake (12%, p?=?0.03) and in specific regions ( p?

SUBMITTER: Honkala SM

PROVIDER: S-EPMC6168908 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Short-term interval training alters brain glucose metabolism in subjects with insulin resistance.

Honkala Sanna M SM Johansson Jarkko J Motiani Kumail K KK Eskelinen Jari-Joonas JJ Virtanen Kirsi A KA Löyttyniemi Eliisa E Knuuti Juhani J Nuutila Pirjo P Kalliokoski Kari K KK Hannukainen Jarna C JC

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20170929 10

Brain insulin-stimulated glucose uptake (GU) is increased in obese and insulin resistant subjects but normalizes after weight loss along with improved whole-body insulin sensitivity. Our aim was to study whether short-term exercise training (moderate intensity continuous training (MICT) or sprint interval training (SIT)) alters substrates for brain energy metabolism in insulin resistance. Sedentary subjects ( n = 21, BMI 23.7-34.3 kg/m<sup>2</sup>, age 43-55 y) with insulin resistance were rando ...[more]

PMID: 28959911

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Short-term interval training alters brain glucose metabolism in subjects with insulin resistance.

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Short-term interval training alters brain glucose metabolism in subjects with insulin resistance.

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