Dataset Information

Efficacy of different faecal microbiota transplantation protocols for Clostridium difficile infection: A systematic review and meta-analysis.

ABSTRACT:

Background

Protocols for treating recurrent Clostridium difficile infection (rCDI) through faecal microbiota transplantation (FMT) are still not standardised. Our aim was to evaluate the efficacy of different FMT protocols for rCDI according to routes, number of infusions and infused material.

Methods

MEDLINE, Embase, SCOPUS, Web of Science and the Cochrane Library were searched through 31 May 2017. Studies offering multiple infusions if a single infusion failed to cure rCDI were included. Data were combined through a random effects meta-analysis.

Results

Fifteen studies (1150 subjects) were analysed. Multiple infusions increased efficacy rates overall (76% versus 93%) and in each route of delivery (duodenal delivery: 73% with single infusion versus 81% with multiple infusions; capsule: 80% versus 92%; colonoscopy: 78% versus 98% and enema: 56% versus 92%). Duodenal delivery and colonoscopy were associated, respectively, with lower efficacy rates (p?=?0.039) and higher efficacy rates (p?=?0.006) overall. Faecal amount???50?g (p?=?0.006) and enema (p?=?0.019) were associated with lower efficacy rates after a single infusion. The use of fresh or frozen faeces did not influence outcomes.

Conclusions

Routes, number of infusions and faecal dosage may influence efficacy rates of FMT for rCDI. These findings could help to optimise FMT protocols in clinical practice.

SUBMITTER: Ianiro G

PROVIDER: S-EPMC6169051 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Publications

Efficacy of different faecal microbiota transplantation protocols for <i>Clostridium difficile</i> infection: A systematic review and meta-analysis.

Ianiro Gianluca G Maida Marcello M Burisch Johan J Simonelli Claudia C Hold Georgina G Ventimiglia Marco M Gasbarrini Antonio A Cammarota Giovanni G

United European gastroenterology journal 20180603 8

<h4>Background</h4>Protocols for treating recurrent <i>Clostridium difficile</i> infection (rCDI) through faecal microbiota transplantation (FMT) are still not standardised. Our aim was to evaluate the efficacy of different FMT protocols for rCDI according to routes, number of infusions and infused material.<h4>Methods</h4>MEDLINE, Embase, SCOPUS, Web of Science and the Cochrane Library were searched through 31 May 2017. Studies offering multiple infusions if a single infusion failed to cure rCD ...[more]

PMID: 30288286

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