Ontology highlight
ABSTRACT:
SUBMITTER: Kim YS
PROVIDER: S-EPMC6169573 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Kim Young Seob YS Park Hyun Jin HJ Park Jung Hwa JH Hong Eun Ji EJ Jang Gun-Young GY Jung In Duk ID Han Hee Dong HD Lee Seung-Hyun SH Vo Manh-Cuong MC Lee Je-Jung JJ Yang Andrew A Farmer Emily E Wu T-C TC Kang Tae Heung TH Park Yeong-Min YM
Oncoimmunology 20180815 10
Dendritic cell (DC)-based vaccines are recognized as a promising immunotherapeutic strategy against cancer. Various adjuvants are often incorporated to enhance the modest immunogenicity of DC vaccines. More specifically, many of the commonly used adjuvants are derived from bacteria. In the current study, we evaluate the use of apoptosis inhibitor 5 (API5), a damage-associated molecular pattern expressed by many human cancer cells, as a novel DC vaccine adjuvant. We showed that API5 can prompt ac ...[more]