Ontology highlight
ABSTRACT:
SUBMITTER: Ghose J
PROVIDER: S-EPMC6169590 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Ghose Jayeeta J Viola Domenico D Terrazas Cesar C Caserta Enrico E Troadec Estelle E Khalife Jihane J Gunes Emine Gulsen EG Sanchez James J McDonald Tinisha T Marcucci Guido G Kaur Balveen B Rosenzweig Michael M Keats Jonathan J Rosen Steven S Krishnan Amrita A Satoskar Abhay R AR Hofmeister Craig C CC Pichiorri Flavia F
Oncoimmunology 20180723 10
Daratumumab (Dara), a human immunoglobulin G1 kappa (IgG1κ) monoclonal anti-CD38 antibody, has been approved by the U.S. Food and Drug Administration for the treatment of relapsed multiple myeloma (MM) as a single agent as well as in combination with immunomodulatory drugs (IMiDs) and proteasome inhibitors (PI). Although the scientific rationale behind the use of Dara in combination with IMiDs has been extensively explored, the molecular mechanisms underlying Dara-PI regimens have not yet been i ...[more]