Ontology highlight
ABSTRACT:
SUBMITTER: Brummelman J
PROVIDER: S-EPMC6170179 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Brummelman Jolanda J Mazza Emilia M C EMC Alvisi Giorgia G Colombo Federico S FS Grilli Andrea A Mikulak Joanna J Mavilio Domenico D Alloisio Marco M Ferrari Francesco F Lopci Egesta E Novellis Pierluigi P Veronesi Giulia G Lugli Enrico E
The Journal of experimental medicine 20180828 10
CD8<sup>+</sup> T cells infiltrating tumors are largely dysfunctional, but whether a subset maintains superior functionality remains ill defined. By high-dimensional single cell analysis of millions of CD8<sup>+</sup> T cells from 53 individuals with lung cancer, we defined those subsets that are enriched in tumors compared with cancer-free tissues and blood. Besides exhausted and activated cells, we identified CXCR5<sup>+</sup> TIM-3<sup>-</sup> CD8<sup>+</sup> T cells with a partial exhausted ...[more]