Unknown

Dataset Information

0

Screening of ligands for redox-active europium using magnetic resonance imaging.


ABSTRACT: We report a screening procedure to predict ligand coordination to EuII and EuIII using magnetic resonance imaging in which bright images indicate complexation and dark images indicate no complexation. Here, paramagnetic GdIII is used as a surrogate for EuIII in the screening procedure to enable detection with magnetic resonance imaging. The screening procedure was tested using a set of eight ligands with known coordination to EuII and EuIII, and results were found to be consistent with expected binding. Validation of the screening procedure with known coordination chemistry enables use with new ligands in the future.

SUBMITTER: Corbin BA 

PROVIDER: S-EPMC6170736 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Screening of ligands for redox-active europium using magnetic resonance imaging.

Corbin Brooke A BA   Basal Lina A LA   White Susan A SA   Shen Yimin Y   Haacke E Mark EM   Fishbein Kenneth W KW   Allen Matthew J MJ  

Bioorganic & medicinal chemistry 20180404 19


We report a screening procedure to predict ligand coordination to Eu<sup>II</sup> and Eu<sup>III</sup> using magnetic resonance imaging in which bright images indicate complexation and dark images indicate no complexation. Here, paramagnetic Gd<sup>III</sup> is used as a surrogate for Eu<sup>III</sup> in the screening procedure to enable detection with magnetic resonance imaging. The screening procedure was tested using a set of eight ligands with known coordination to Eu<sup>II</sup> and Eu<sup  ...[more]

Similar Datasets

| S-EPMC6726119 | biostudies-literature
| S-EPMC6772179 | biostudies-literature
| S-EPMC3607631 | biostudies-literature
| S-EPMC4186673 | biostudies-literature
| S-EPMC5501313 | biostudies-literature
| S-EPMC3137231 | biostudies-literature
| S-EPMC8241703 | biostudies-literature
2018-12-01 | GSE101908 | GEO
| S-EPMC3321733 | biostudies-literature
2023-11-03 | GSE239379 | GEO