Ontology highlight
ABSTRACT:
SUBMITTER: Li F
PROVIDER: S-EPMC6172261 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Li Feifei F Wei Aili A Bu Lijuan L Long Long L Chen Wei W Wang Chen C Zhao Changqi C Wang Lili L
Cell death & disease 20181004 10
Procaspase-3-activating compound 1 (PAC-1) induces procaspase-3 activation via zinc chelation. However, whether PAC-1 employs other mechanisms remains unknown. Here we systematically screened for potent PAC-1 targets using 29 enhanced green fluorescent protein-labeled reporter cell lines and identified hypoxia-inducible factor 1α (HIF1α) and RAD51 pathways as PAC-1 targets. These results were verified in HepG2 cells and two other cancer cell lines. Mechanistically, PAC-1 specifically blocked HIF ...[more]