Ontology highlight
ABSTRACT:
SUBMITTER: Ferlin A
PROVIDER: S-EPMC6172310 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Frontiers in endocrinology 20180928
Androgens are primarily involved in muscle growth, whilst disease-driven muscle wasting is frequently associated with hypogonadism. The Leydig cells of the testes also produce the peptide-hormone Insulin-like peptide 3 (INSL3). INSL3 displays anabolic activity on bone, a target tissue of androgens, and its plasma concentrations are diminished in male hypogonadism. Here we tested the role of INSL3 on muscle mass regulation, in physiological and pathological conditions. Studies on C2C12 cell line ...[more]