Ontology highlight
ABSTRACT:
SUBMITTER: Deshpande TM
PROVIDER: S-EPMC6173052 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Deshpande Tanvi M TM Pagare Piyusha P PP Ghatge Mohini S MS Chen Qiukan Q Musayev Faik N FN Venitz Jurgen J Zhang Yan Y Abdulmalik Osheiza O Safo Martin K MK
Acta crystallographica. Section D, Structural biology 20181002 Pt 10
Increasing the affinity of hemoglobin for oxygen represents a feasible and promising therapeutic approach for sickle cell disease by mitigating the primary pathophysiological event, i.e. the hypoxia-induced polymerization of sickle hemoglobin (Hb S) and the concomitant erythrocyte sickling. Investigations on a novel synthetic antisickling agent, SAJ-310, with improved and sustained antisickling activity have previously been reported. To further enhance the biological effects of SAJ-310, a struct ...[more]