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CD22: A Regulator of Innate and Adaptive B Cell Responses and Autoimmunity.

ABSTRACT: CD22 (Siglec 2) is a receptor predominantly restricted to B cells. It was initially characterized over 30 years ago and named "CD22" in 1984 at the 2nd International workshop in Boston (1). Several excellent reviews have detailed CD22 functions, CD22-regulated signaling pathways and B cell subsets regulated by CD22 or Siglec G (2-4). This review is an attempt to highlight recent and possibly forgotten findings. We also describe the role of CD22 in autoimmunity and the great potential for CD22-based immunotherapeutics for the treatment of autoimmune diseases such as systemic lupus erythematosus (SLE).

SUBMITTER: Clark EA

PROVIDER: S-EPMC6173129 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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CD22: A Regulator of Innate and Adaptive B Cell Responses and Autoimmunity.

Clark Edward A EA Giltiay Natalia V NV

Frontiers in immunology 20180928

CD22 (Siglec 2) is a receptor predominantly restricted to B cells. It was initially characterized over 30 years ago and named "CD22" in 1984 at the 2nd International workshop in Boston (1). Several excellent reviews have detailed CD22 functions, CD22-regulated signaling pathways and B cell subsets regulated by CD22 or Siglec G (2-4). This review is an attempt to highlight recent and possibly forgotten findings. We also describe the role of CD22 in autoimmunity and the great potential for CD22-ba ...[more]

PMID: 30323814

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