Ontology highlight
ABSTRACT:
SUBMITTER: van Nieuwenhuijze A
PROVIDER: S-EPMC6173157 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
van Nieuwenhuijze Annemarie A Burton Oliver O Lemaitre Pierre P Denton Alice E AE Cascalho Ana A Goodchild Rose E RE Malengier-Devlies Bert B Cauwe Bénédicte B Linterman Michelle A MA Humblet-Baron Stephanie S Liston Adrian A
Frontiers in immunology 20180928
The nucleopore is an essential structure of the eukaryotic cell, regulating passage between the nucleus and cytoplasm. While individual functions of core nucleopore proteins have been identified, the role of other components, such as Nup210, are poorly defined. Here, through the use of an unbiased ENU mutagenesis screen for mutations effecting the peripheral T cell compartment, we identified a Nup210 mutation in a mouse strain with altered CD4/CD8 T cell ratios. Through the generation of Nup210 ...[more]